Stock Art | Clark Medical Illustration

Yeast and Neurodegenerative Disease Research

The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.

Bacteriophages

Bacteria-infecting viruses, or bacteriophages look like they were created for a sci-fi movie, but they really are naturally occurring viruses that selectively target and kill specific bacterial strains and are harmless to humans, animals, and plants.

Neurobiological Pathways Linked to Suicide Risk

Scientists have identified several key neurobiological pathways with ties to suicidal behaviors. Three of the systems best-studied in relation to suicide are depicted in this infographic.

Alzheimer’s Markers in the Blood

A dark and stormy look at biological markers in the blood that can lead to earlier Alzheimer’s diagnosis and treatment.

Patent Foramen Ovale (PFO) Closure

This journal cover illustration was created for an article about patent foramen ovale closure for secondary stroke prevention. There are a variety of devices available for PFO closure, so we chose to show the patent foramen ovale defect rather than focus on a specific device or technique for closure.

Anastasis (Cell Death Reversal)

Journal infographic for an article about anastasis (cell death reversal). Molecular processes can rescue cells already engaged in the process of apoptosis or other forms of programmed cell death.

Future Treatments of Secondary Mitral Regurgitation

Journal cover illustration for an article detailing the results from two trials (COAPT and MITRA-FR) that examined transcatheter mitral valve repair in patients with heart failure and secondary mitral regurgitation.

FFR and iFR used to Evaluate Coronary Stenosis

FFR and iFR are both indices that use the concept of flow reserve to evaluate the severity of a coronary stenosis.

Hernia Graft Placement | © Lisa A. Clark

Abdominal Hernia Graft Placement

The image was used by the graft manufacturer to show placement options for the biological graft including onlay, retromuscular, preperitoneal and intraperitoneal placement.

Perineuronal Nets (PNNs)

Perineuronal nets form during postnatal development, marking the end of what’s known as the “critical period” of heightened brain plasticity. PNNs are composed of extracellular matrix (ECM) molecules and are responsible for synaptic stabilization in the adult brain. PNNs are found around certain neuron cell bodies and proximal neurites in the central nervous system. Increasingly, researchers are turning to PNNs as potential targets to enhance plasticity for the treatment of various diseases. This illustration was created for the cover The Scientist magazine.

Blood-Brain Barrier

The blood-brain barrier (BBB) is a collection of specific cells and proteins that control the movement of molecules from the blood to the central nervous system (CNS).

Cardiogenic Shock

Cardiogenic shock occurs when the heart can't pump enough blood to the body. Cardiogenic shock is the leading cause of death in acute myocardial infarction. Symptoms of cardiogenic shock include rapid breathing and heartbeat (tachycardia), mental confusion, sweating, weak pulse and poor tissue perfusion.

Ankle Fracture

Pilon fractures are injuries that occur at the lower end of the tibia and involve the weight bearing surface of the ankle joint. The fibula may also be broken.

Endovascular Thrombectomy

Endovascular thrombectomy has been shown to benefit patients with acute stroke and large-vessel occlusions. This illustration was created for a journal article tracking to what extent these technologies have taken off, and to what extent interventional cardiologists are actually using them.

Bioabsorbable Stenting Technology

Metal stents can aggravate vessels and cause stent thrombosis that prevents vessel remodeling. They can also impair future surgical interventions and impede CT or MR imaging. Bioabsorbable stent technology is an alternative to traditional metal stents. In dissolving stents the entire scaffold is gradually absorbed by the body over time.

Left Atrial Appendage Thrombus

Left atrial appendage thrombi (fibrinous clots that form in blood vessels or heart chambers) are often caused by acute atrial fibrillation.

Transcatheter Aortic Valve Replacement (TAVR)

Journal cover illustration about transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis at intermediate or low risk for surgery. Currently, the two TAVR devices approved in the US are indicated only for patients at high risk or extreme risk/inoperable, but the literature is now showing that TAVR benefits patients intermediate or low risk for surgery.

Carotid Artery Blockage Leading to a Stroke

The illustration was for a journal article about the endovascular options for the treatment of stroke.

Drug-coated Balloons for Peripheral Artery Disease (PAD)

My recent journal cover art about the use of drug-coated balloons to treat occluded below-the-knee arteries.

Carotid Artery Stenting

Carotid Artery Stenting art for a journal article discussing recent CREST-2 trial data that indicates carotid artery stenting (CAS) is not inferior to carotid endarterectomy.

Heart Failure and Heart Anatomy

More interventional techniques are being used to improve outcomes for patients with heart failure. This medical illustration was created to accompany a journal article’s cover story.

Taxol Producing Fungi in Yew Trees

Yew trees have a built-in, fungal security force. My recent illustration for The Scientist magazine shows Taxol-producing fungi battling with pathogenic fungi. Taxol is used in anti-cancer drugs and harvested from yew trees.

Catheter-Directed Atherectomy

Atherectomy is a minimally invasive endovascular technique for removing plaque build-up from blood vessels in the heart and in other areas of the body.

Cardiovascular System

Cardiology journal illustration depicting the human cardiovascular system including the heart and major arteries and veins.

Dual Antiplatelet Therapy

Journal cover image about duration of dual antiplatelet therapy following angioplasty. Antiplatelet medicines work to keep platelets from sticking together and forming blood clots.

Drug Eluting Angioplasty ©2015 Lisa A. Clark

Drug-Coated Balloon Angioplasty for Peripheral Artery Disease (PAD)

Drug-coated balloons for the treatment of peripheral artery disease have the potential to reduce the incidence of restenosis without having to leave anything behind.

Dissolving Stent

The future of treating coronary artery disease may lie in bioresorbable scaffolds. This image was created for a journal article about cardiovascular stents that dissolve in the artery over time.

Coronary Artery Stent

Stents are used to treat coronary artery disease and allow blood to flow through the artery. This image was created for a cardiology journal.

Female Pelvic Floor

The pelvic floor is made of several muscle layers that form a bowl shape within the pelvis. This image illustrates a side view of the uterus, bladder, rectum and pelvic floor muscles.

Carotid Stenosis

Carotid stenosis is a condition in which the carotid arteries become narrowed or blocked. This image was used for a medical journal cover.

Osteoarthritis of the Hip

Osteoarthritis occurs when inflammation and injury to a joint cause cartilage tissue to break down. The breakdown of cartilage causes pain, inflammation, and deformity.

Frill Neck Lizard

Chlamydosaurus has a frill of folded skin that normally lies around the back of the head that is erected when the lizard is threatened. These bipedal lizards can run very quickly and sometimes appear to be walking on water.

Apophyseal Avulsion Fractures of the Hip and Pelvis

Apophyseal avulsion fractures of the hip and pelvis are injuries that usually occur in the adolescent athlete. This illustration was used for a medical journal cover.

Femoral Tunnel Drilling for ACL Reconstruction

A femoral tunnel was created to aid with anterior cruciate ligament (ACL) reconstruction. This image was created for an orthopedic journal cover.

Crown: Tooth Prepared for Crown

Crown: White Crown Near Final Position

Crown: White Crown in Final Position

Crown: Gold Crown in Final Position

Dentures: Full Dentures in Place

Dentures: Missing Teeth

Dentures: Partial Dentures

Drifting

Teeth on either side of missing tooth have drifted toward the space, lower tooth has drifted upward into space.

Dental Fillings 1: Progressive Tooth Decay

Progressive tooth decay

Dental Fillings 1: Tooth Prepared for Filling

Tooth prepared for filling.

Dental Fillings 1: Tooth Filled with White Filling Material

Tooth filled with white filling material

Dental Fillings 1: Tooth Filled with Silver Filling Material

Tooth filled with silver filling material

Dental Fillings 2: Progressed Tooth Decay

Molar with large dark area of decay.

Dental Fillings 2: Progressive Tooth Decay (Cross Section)

Molar cross section with large dark area of decay. Decay has come close to pulp tissue.

Dental Fillings 2: Basing Material

Molar cross section with large dark area of decay. Decay has come close to pulp tissue. Deep area has been filled in with “basing material”.

Dental Fillings 2: Tooth Filled with White Filling Material

Molar cross section with large dark area of decay. Decay has come close to pulp tissue. Deep area has been filled in with “basing material”. Tooth is filled with white filling material.

Dental Fillings 2: Tooth Filled with Silver Filling Material

Molar cross section with large dark area of decay. Decay has come close to pulp tissue. Deep area has been filled in with “basing material”. Tooth is filled with silver filling material.

Dental Home Care: Holding Floss

Dental Home Care: Floss Properly Placed Between Teeth

Dental Home Care: Brush Properly Placed Next to Teeth

Dental Home Care: Proper Brush Placement

Dental Home Care: End Tuft Brush Properly Placed Next to Teeth

Dental Home Care: Proxi-brush Properly Placed Between Teeth

Impacted Wisdom Tooth: Soft Tissue Impacted

Impacted Wisdom Tooth: “Partial Bony” Impacted

Impacted Wisdom Tooth “Full Bony” or “Horizontally” Impacted

Impacted Wisdom Tooth: “Distally” Impacted

Dental Implant: Good Bone Support Below Gingival Tissue

Dental Implant: Implant in Bone

Dental Implant: Crown near Final Position

Dental Implant: Crown in Final Position

Skin Cross Section

Skin is made up of two layers that cover a third fatty layer. This illustration includes the epidermis, dermis and subcutaneous tissue. It includes nerves, sweat glands, oil glands, and hair follicles. The image was used in patient education materials.

Dental Inlay: Tooth prepared for Inlay

Dental Inlay: Inlay Near Final Position

Dental Inlay: Inlay in Final Position

Dental Onlay: Onlay in Final Position

Dental Onlay: Onlay Near Final Position

Dental Onlay: Tooth Prepared for Onlay

Dental Post 1: Build Up Material in Place

Dental Post 1: Prefabricated Post in Place

Dental Post 1: Damaged Tooth

Dental Retention Pin

Dental Post 2: Custom Cast Post in Place

Dental Post 2: Custom Cast Post Nearly in Place

Periodontal 2: Periodontal Probe

A periodontal probe measures the depth of the space between the tooth and gum.

Periodontal 2: Periodontal Probe (Gums Removed)

A periodontal probe measures the depth of the space between the tooth and gum.

Periodontal 5: Severe Periodontitis

Periodontal 4: Advanced Periodontitis (Gingival Tissue)

Periodontal 3: Increased Changes in Bone Architecture

Periodontal 2: Progressive Gum Inflammation

Periodontal 1: Changes in Bone Architecture

Gingivitis 2: Increased Gum Inflammation

Gingivitis 1: Gums Slightly Inflamed

Root Canal: Cross Section of Tooth Requiring Root Canal

Root Canal: Tooth Requiring Root Canal

Root Canal: Cross Section of Tooth Requiring Root Canal

RRoot Canal: Cross Section of Tooth Requiring Root Canal

Root Canal: Pulp Removed

Root Canal: Canals Filled

Root Canal: Final Filling (White Material)

Root Canal: Final Filling (Silver Material)

Sealants: Finished Procedure

Sealants: Sealant Material Cured by Light

Sealants: Sealant Material Applied to Grooves

Sealants: Etchant Applied

Sealants: Tooth with Grooves in Enamel

Dental Veneers: Teeth with Gingival Tissue Showing Gaps Between Teeth

Dental Veneers: Veneers Near Final Position

Dental Veneers: Teeth Prepared for Veneers

Dental Veneers: Veneers in Final Position

TMJ Dysfunction: Condyles in Anterior Position

TMJ Dysfunction: Condyles in Posterior Position

TMJ Dysfunction: Normal Temporamandibular Joint

Sacral Nerve Plexus

Illustration of lumbo-sacral nerve plexus, pelvis, iliac arteries, femoral arteries and lumbar spine.

Teeth Whitening Strips

Teeth whitening strips are a popular home remedy for fixing stained or discolored teeth. This image was created as a marketing piece for a dental product manufacturer.

Rotator Cuff Tear

A rotator cuff tear is a tear in one of the tendons of the four rotator cuff muscles in the shoulder. This illustration was used as a journal cover illustration demonstrating the repair of a u-shaped rotator cuff tear.

Dental Caries (Cavities)

Buccal (frontal) view of molar with dental decay.

Percutaneous Coronary Intervention

Percutaneous coronary intervention (PCI) for chronic total occlusions.

Hip Replacement Failure

Dislocation is an uncommon, but potential complication to hip replacement surgery. This illustration demonstrates the failure of a metal on metal hip implant.

Mastopexy with Biological Graft

This image was used to demonstrate the placement of a new biological graft used in comprehensive breast reconstruction and revision procedures, including mastopexy or "breast lift".

Healthy Teeth

Frontal view of health adult teeth and gums.

Necrotizing Fasciitis

Necrotizing fasciitis (NF), commonly known as flesh-eating disease or Flesh-eating bacteria syndrome, is a rare infection of the deeper layers of skin and subcutaneous tissues, easily spreading across the fascial plane within the subcutaneous tissue.

Superficial Femoral Artery Disease

Journal cover illustration about the difficulties and options for the treatment of superficial femoral artery disease (SFA).

Long Bone Anatomy

Long bones consists of a layer of connective tissue called the periosteum, an outer shell of compact bone with a deeper layer of cancellous bone (spongy bone) which contains red bone marrow.

Hybrid Coronary Revascularization

Hybrid Coronary Revascularization procedure consisting of a minimally invasive left internal mammary artery (LIMA) to left anterior descending (LAD) graft, along with PCI of the circumflex artery.

Percutaneous Heart Failure

This illustration was created for a journal cover about the increasing incidence and treatment options for percutaneous heart failure.

Radial Fracture Plate

A distal radius fracture is surgically repaired with a plate.

Recurrent Hip Instability

This piece was created for an orthopedic journal cover. The feature story was Bipolar Reconstruction for Recurrent Instability of the Hip.

Radial Artery Access for Cardiac Catheterization

This image was used for an interventional cardiology journal cover article on radial artery access for diagnostic coronary angiography and PCI.

Intra-Cytoplasmic Sperm Injection (ICSI)

ICSI involves injecting a single sperm directly into an egg in order to fertilize it. The fertilized egg (embryo) is then transferred to the woman’s uterus.

Shoulder Instability in Young Athletes

This illustration was used as the journal cover art for an article on healthy athletes with a history of shoulder instability.

Buccal or Facial View (Adult Teeth)

Buccal or facial view of the adult (permanent) teeth.

Occlusal View (Adult Teeth)

Occlusal View of the adult (permanent) teeth.

Occlusal View (Adult Teeth)

Occlusal view of the adult (permanent) teeth.

Lingual View (Adult Teeth)

Lingual view of adult (permanent) teeth.