This journal cover illustration was created for an article about patent foramen ovale closure for secondary stroke prevention. There are a variety of devices available for PFO closure, so we chose to show the patent foramen ovale defect rather than focus on a specific device or technique for closure.
![Patent Foramen Ovale (PFO) | ©Lisa A. Clark](https://clark-illustration.com/wp-content/uploads/2019/03/PatForOvale-1024x723.jpg)
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